Electro-oxidative N-Halogcnation of 2-Azetidinone Derivatives.Reaction of N-Halo-2-azetidinones

摘要

Penems and carbapenems have attracted keen interest as promising antibiotics owing to their potent and broad antimicrobial activities as well as excellent metabolic stability.4-Acetoxy-2-azetidinone 1 and N-halo-2-azetidinones 2 have been reported as a key intermediates for synthesis of the important class of beta-lactam antibiotics.We investigated electrolysis of 2-azetidinone 3 affording 1,2a and 2b depending on the choice of the electrolysis media and/or procedure (Scheme 1).