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Long-term outcomes of palliative colonic stenting versus emergency surgery for acute proximal malignant colonic obstruction: a multicenter trial

机译:姑息性结肠支架置入术与急诊手术治疗急性近端恶性结肠梗阻的远期结果:一项多中心试验

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Background and study aims?Long-term data are limited regarding clinical outcomes of self-expanding metal stents as an alternative for surgery in the treatment of acute proximal MBO. The aim of this study was to compare the long-term outcomes of stenting to surgery for palliation in patients with incurable obstructive CRC for lesions proximal to the splenic flexure. Patients and methods?Retrospective multicenter cohort study of obstructing proximal CRC patients with who underwent insertion of a SEMS (n?=?69) or surgery (n?=?36) from 1999 to 2014. The primary endpoint was relief of obstruction. Secondary endpoints included technical success, duration of hospital stay, early and late adverse events (AEs) and survival. Results?Technical success was achieved in 62/69 (89.8?%) patients in the SEMS group and in 36?/36 (100?%) patients who underwent surgery (P?=?0.09). In the SEMS group, 10 patients underwent stenting as a bridge to surgery and 59 underwent stent placement for palliation. Clinical relief was achieved in 78?% of patients with stenting and in 100?% of patients who underwent surgery (P?
机译:背景和研究目的:关于自膨式金属支架作为急性近端MBO手术替代疗法的临床结果的长期数据有限。这项研究的目的是比较无法治愈的梗阻性CRC脾脏近端病变患者的支架置入术和手术缓解的长期效果。患者和方法:1999年至2014年间接受SEMS(n = 69)或手术(n = 36)手术的近端CRC患者的回顾性多中心队列研究。主要终点是缓解阻塞。次要终点包括技术成功率,住院时间,早期和晚期不良事件(AE)和生存率。结果:SEMS组中有62/69(89.8%)的患者和接受手术的36?/ 36(100 %%)的患者获得了技术成功(P <= 0.09)。在SEMS组中,有10例患者接受了支架置入术以作为手术的桥梁,而59例接受了支架置入术以缓解症状。在有支架的患者中有78%的患者和在接受手术的患者中有100%的患者获得了临床缓解(P 0.001)。与外科手术组相比,患有SEMS的患者的急性AE明显更少(7.2%vs. 30.5%,P == 0.003)。 SEMS组的医院死亡率为0%,而手术组为5.6%(P = 0.11)。与手术组(8天)相比,SEMS组的患者中位住院时间(4天)明显缩短(P <0.01)。 SEMS组(73.9%)的维持减压而无肠梗阻复发直至死亡或最后一次随访的情况低于手术组(97.3 %%; P = 0.003)。与手术相比,SEMS的长期并发症发生率更高(21%和11%P == 0.27)。晚期SEMS不良事件包括阻塞(10%),迁移(5%)和结肠溃疡(6%)。 120周时,SEMS组的生存率为5.6%,而手术组为0%(P = 0.8)。结论:与SEMS相比,手术治疗与近端结肠梗阻相关的技术和临床成功率更高,但手术与住院时间更长和早期AE较多相关。对于急性近端MBO患者,应考虑将SEMS作为治疗的初始方式,并且应保留手术治疗SEMS的失败,因为手术涉及较高的发病率和死亡率。

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