EVALUATION OF CYSTICLEAN? CAPSULES, A CRANBERRY EXTRACT WITH HIGH ANTI-ADHESION ACTIVITY, AS MONOTHERAPY IN UNCOMPLICATED CYSTITIS: AN OBSERVATIONAL PILOT STUDY

摘要

Background:Cysticlean? is a cranberry extract product with a high quantity of proanthocyanidins (240 mg/capsule)with a significant dose-dependent anti-adhesion activity of Escherichia coli (EC) adhered to uroepithelial cells.Previous clinical assays showed that Cysticlean? is a product highly recommended in the prophylaxis and treatmentof UTIs. The aim of this study is the evaluation of Cysticlean as an alternative to antibiotics to treat uncomplicatedcystitis.Material and Methods This observational study included 30 consecutive ambulatory patients (17 women and 13men), who were diagnosed of uncomplicated cystitis (UC) and agreed to participate in this observational study.Patients were informed to come to visit the doctor again after 15 days after Cysticlean? treatment was started (1capsule of Cysticlean? every 12 h daily) and immediately if signs/symptoms did not disappear. In this case,Cysticlean? was stopped and patients treated with antibiotic.Results: 21 patients were successfully cured with Cysticlean? treatment only (70%) and 9 patients needed antibioticto cure their UC. 82.35% of women and 53.,85% of men did not need antibiotic to be cured. No significantdifferences at baseline were found regarding signs/symptoms severity between those patients cured with extract aloneand those who needed antibiotic. No side effects/adverse reactions were reported.Conclusions: These preliminary data strongly suggest that Cysticlean? could be considered as an alternative toantibiotics for a 1st line treatment of UC. Further clinical studies to confirm whether Cysticlean? could be analternative to antibiotic treatment for UC and this approach could contribute to reduce world-wide growing antibioticresistance.