Prevention of Agitation on Emergence in Children Undergoing Tonsillectomy under Sevoflurane Anesthesia: A Comparison of Ketamine and Propofol

摘要

OBJECTIVE : To compare the efficacy of Ketamine with Propofol, in pediatric patients undergoing tonsillectomy with sevoflurane anesthesia, in terms of frequency of emergence agitation. STUDY DESIGN: A randomized control trial PLACE AND DURATION: At the Department of Anesthesia Holy Family Hospital, Rawalpindi from 20th April, 2015 to 19th October, 2015. METHODOLOGY: The children between 2-7 years age and belonged to ASA class I or II undergoing tonsillectomy were pre-medicated with 0.3 mg/kg oral midazolam 30 min before induction. The children were randomly allocated to two equal groups i.e. to receive either intravenous Ketamine 0.5 mg/kg (Group A) or Propofol 1mg/kg (Group B) which is given 5 minutes before the end of surgery. The presence or absence of Emergence Agitation was assessed using Aono's four point scale upon admission to the post anesthesia care unit and every 5 minutes thereafter for the first 30 minutes, by an anesthesiologist blinded to the study groups. RESULTS: The efficacy of Ketamine in preventing Emergence Agitation was 84% whereas Propofol had an efficacy of 72%. The difference between the two groups was not statistically significant. (P=0.076). CONCLUSION: There is no statistically significant difference between the efficacy of Ketamine and Propofol, in preventing Emergence Agitation in children undergoing tonsillectomy under Sevoflurane anesthesia.