Association of PPARαIntron 7 Polymorphism with Coronary Artery Disease: A Cross-Sectional Study

摘要

The allelic variants of peroxisome proliferator-activated receptor alpha (PPARα) can influence the risk of coronary artery disease (CAD) by virtue of its effect on lipid metabolism. However, the role of PPARαintronic polymorphism with CAD has received little attention. The association of allelic variants G/C at intron 7 of the PPAR-alpha gene with CAD was examined in a hospital-based Indian population. PPAR genotyping was performed in 110 male patients with CAD and 120 age and ethnically matched healthy males by PCR amplification of the gene followed by restriction digestion. Presence of C allele showed a positive association with CAD (OR=2.9; 95% CI [1.65–4.145];P=.009) and also with dyslipidaemia (OR=2.95, 95% CI (1.5–4.39);P<.05). Impaired lipid metabolism in carriers of the PPARαIntron 7C allele is possibly responsible for the predilection to CAD.