An Efficient and Facile Synthesis of 1,2,4-Aryl Triazoles and 4-Thiazolidinones Bearing 6-Fluorochroman Nucleus

摘要

A new generation of chroman bearing heterocyclic five membered ring such as 1,2,4-triazoles and thiazolidinones was designed and synthesized. New chroman based nucleus 5-(6-fluorochroman-2-yl)-4-aryl-4H-1,2,4-triazole-3-thiol and 6-fluorochroman-N-(4-oxo-2-arylthiazolidinin-3-yl) chroman-2-carboxamides were synthesized. Aryl triazole compounds4a–4jwere synthesized from 6-fluorochroman-2-carbohydrazide2on reaction with base in methanol and CS2followed by reaction with substituted aniline. Thiazolidinone compounds5a–5jwere synthesized from 6-fluorochroman-2-carbohydrazide2on reaction with substituted aryl aldehyde and thioglycolic acid.