Vitamin C can reduce toxic effects of Nano Zinc Oxide

摘要

Nanoparticles are extensively employed in most industries and biological sciences. Zinc nanoparticles have widespread application in industries manufacturing medical equipment as well as household because of its unique features such as immediate effect, greater stability, and antimicrobial properties and special factors. Therefore many peoples are exposure to nanoparticles that maybe have harmful side effects. Detrimental effects of zinc oxide nanoparticles were the objective of different previous studies whit various aspects. Aim of the present research was investigation of the damages of zinc oxide nanoparticles on the liver cellsand blood factors in Wistar rats. Also this study assessed the role of vitamin C in the reduction of toxic effects of nanoparticles on the mentioned factors.36 male rats with approximately 35 days age were divided in to six groups with 6 rats separated. The rats in the experimental groups were administrated by two acute doses of nanoparticles 200 and 400 mg/kg. After 7 days rats blood samples were prepared, then AST, ALT, ALP levels measured and WBC and placket numbered. obtained results demonstrated a significant increasing in the number of WBC in the experimental groups compared to the control. Results showed rise of the liver enzymes concentration in the blood but application of vitamin C inhibit this result.This response was dose dependent and was more significant in high dose (p0/05).Our results demonstrated that zinc oxide nanoparticles interrupt the function of liver cell membrane so cause diffusion of liver enzymes to blood. By using of an antioxidant agent such as vitamin C toxic effects of nanoparticles reduced. This indicates one of more important ways of nanoparticles damaging is oxidative stress.