“TRIAZINE BASED DENDRIMER AS SOLUBILITY ENHANCERS OF KETOPROFEN: EFFECT OF CONCENTRATION, PH AND GENERATION”

摘要

Objective: To synthesize novel dendritic architecture from N,N'-biz(4,6-dichloro-1, 3,5-triazin-2-yl)propane-1,3-diamine as core. To apply of different generations of synthesized triazine based dendrimer (G1-G3) to improve aqueous solubility of hydrophobic drug Ketoprofen and to study the effect of concentration, pH and generation on aqueous solubility of Ketoprofen. Methods: Triazine based dendrimer was synthesized up to generation 3 using divergent method. Synthesized dendrimer generations were characterized by FT-IR, 1H-NMR and1 3C-NMR. Potential of full generation triazine based dendrimers (G1-G3) as solubility enhancers of Ketoprofen were investigated by Higuchi and Connors method at different dendrimer concentrations, pH and generations. Results: Triazine based dendrimer significantly enhances solubility of Ketoprofen by either hydrophobic interaction or hydrogen bonding or both. Conclusion: Synthesized triazine based dendrimers (G1-G3) enhances solubility of Ketoprofen in water. Solubility of Ketoprofen increased with increase in concentration of the dendrimer, pH and dendrimer generation