EVALUATION OF IN VITRO ANTI-INFLAMMATORY ACTIVITY OF STEM BARK EXTRACTS OF MESUA FERREA LINN.

摘要

Objective: Phytochemical evaluation and in vitro anti-inflammatory activity of stem bark extracts of Mesua ferrea Linn. Methods: Petroleum ether, chloroform, and 80% ethanol extracts were used for in-vitro bioassays: such as Human red blood cells membrane stabilization, protein inhibitor, inhibition of egg albumin and anti-lipoxygenase assay to evaluate their anti-inflammatory potential. Results: Phytochemical analysis revealed the presence of phenols, flavonoids, alkaloids, steroids, saponins, tannins, glycosides, and terpenoids. The petroleum ether, chloroform, and 80% ethanol extracts showed significant reduction in inflammation at different 100, 200 and 500μg/ml compared to standard drug indomethacin (100μg/ml). Conclusion : Based on the results, it can be concluded that the 80% ethanol extract of stem bark of Mesua ferrea Linn. ( M. ferrea ) exhibited significant anti-inflammatory activity compared to petroleum ether and chloroform extracts. Keywords: Mesua ferrea Linn. Phytochemicals, Anti-inflammatory.