ENHANCEMENT OF DISSOLUTION RATE OF IBUPROFEN BY PREPARING SOLID DISPERSION USING DIFFERENT METHODS

摘要

Ibuprofen. is. (NSAID). non‐steroidal. anti‐inflammatory. drug. and. used. as. analgesic. &. anti‐inflammatory. drug.. It. can. be. also. used. in. the.treatment.of.rheumatoid.arthritis,.osteoarthritis,.and.primary. dysmenorrhea..Ibuprofen.is.absorbed.rapidly,.bound.avidly.to.protein,.but.it.has. low. aqueous. solubility. so,.it. also. lowers. the. dissolution. profile.of.drug..To.overcome.this.problem,.various.techniques.are. used,. like.solid.dispersion,.complexation,.co‐solvency,.hydrotrophy,.nano.technology.approach..In.this.study,.the.dissolution.rate.of.poorly.soluble.drug.Ibup rofen.was.increased.by.preparing.solid.dispersion.with.urea.in. ratio.of.(1:1),.(1:3).&.(1:5). by. using.melt.dispersion.method.&. solvent.evaporation.method..The. rate.of.dissolution.of.Ibuprofen.was.increased.with.the.proportion. of