PRECLINICAL STUDIES OF VARIOUS EXTRACTS OF POLYALTHIA LONGIFOLIA FOR THE MANAGEMENT OF DEXAMETHASONE INDUCED OSTEOPOROSIS IN RATS

摘要

Polyalthia longifolia is known to be used traditionally for the treatment of many diseases such as helminthiasis, diabetes and hypertension etc., and it is not investigated earlier for the treatment of osteoporosis. The aim of the present work is to investigate the effects of Polyalthia longifolia for the management of dexamethasone induced osteoporosis in rats. Female Wister rats were used to investigate antiosteoporotic activity of various extracts i.e. petroleum ether, chloroform, ethyl acetate, ethanol and water of Polyalthia longifolia at the dose of 100mg/kg b. wt. and 200mg/kg b.w. and observed various parameters i.e. alkaline phosphatase estimation, change in body weight, bone density, bone mechanical strength, and ash value were determined in dexamethasone induced osteoporosis. Alkaline phosphatase (ALP) level was found to be increased in osteoporotic group than normal control group. Ethyl acetate extract shows best results in bone density and percentage ash value. While aqueous extract shows best results in biomechanical strength and body weight of rats. The results obtained in the present study provide evidence that Polyalthia longifolia contributes to the healing of osteoporosis