NEW SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS DETERMINATION OF AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM IN TABLET DOSAGE FORMS

摘要

Two.simple,.accurate,.precise,.reproducible,.requiring.no.prior.separation.and. economical.procedures.for.simultaneous.estimation. of.Amlodipine.besylate.(AMD).and.Atorvastatin.calcium.(ATR).in.tablet.dosage.form.have.been.developed..First.method.is.simultaneous.equation.method;.in.this.method.361nm.and.246.nm.were.selected.to.measure.the.absorbance.of.drugs.at.both.wavelengths..The.second.method.is.Q‐value.analysis.based.on.measurement.of.absorptivity.at.238.8.nm.(as.an.iso‐absorptive.point).and.246.nm..AMD.and.ATR.at.their.respective.maximum.wavelength.361.nm. and. 246. nm. and. at. isoabsorptive. point. 238.8. nm. shows. lineari ty. in. a. concentration. range. of. 0.5‐30. μg/mL.. Recovery. studies. range. from.>99.82%.for.AMD.and.>98.09%.for.ATR.in.case.of.simultaneous.equation.method.and.>100%.for.AMD.and.>98.45%.for.ATR.in.case.of.Q‐analysis.method.confirming.the.accuracy.of.the.proposed.method..The.proposed.methods.are.recommended.for.routine.analysis.since.it.is. rapid,. simple,.accurate.and.also.sensitive.and.specific.(no.heating.and.no.organic.solvent.extraction.is.required).