A NOVEL METHOD FOR SIMULTANEOUS QUANTIFICATION OF AMLODIPINE BESYLATE AND TELMISARTAN IN TABLET

摘要

A process is disclosed for simultaneous quantification of Amlodipine besylate and telmisartan in tablet. The process further includes spectrophotometric calculation. In addition, the process involves formation and solving of simultaneous equation at 297.0 nm for estimation of telmisartan and amlodipine besylate is estimated from the calibration curve at 362.0 nm. Alternatively, the process may use absorbance ratio method using 324.0 nm as isobestic point for estimation of telmisartan. In alternative to other methods first derivative spectroscopy using 236.0 nm as zero crossing point is used for estimation of telemisartan. Methanol and 0.1 N sodium hydroxide in is used as solvent.