PREPARATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF PHENYTOIN SODIUM USING NATURAL POLYMERS

摘要

The.aim.of.the.present.study.was.to.develop.sustained.release.matrix.tablets.of.phenytoin.sodium.an.antiepileptic.drug..Advantages.of.sustained‐release.tablets.are.that.they.can.often.be.taken.less.frequently.than.instant.release.formulations.of.the.same.drug,.and.that.they.keep.steady.levels.of.the.drug. in. the. blood.stream..The. tablets. were. fabricated.by.the.wet.granulation.method.using.water.as.granulating.agent.along. with. matrix.materials.like.guar.gum,.sodium.alginate,.tragacanth.and.xanthan. gum.with.varying.percentage..The.granules.were.evaluated. for.angle.of.repose,.bulk.density,.compressibility.index,.total.porosity,.and.drug.content..The.tablets.were. subjected.to.weight.variation.test,.drug.content,. hardness,.friability,. and. in.vitro.release.studies.. The. swelling. behavior. of. matrix. was.also. investigated.. The.granules. showed. satisfactory. flow.properties,.compressibility,. and. drug.content.. The.I.R. spectral. analysis.studies.confirmed.no.interaction. between.phenytoin.with.used. natural. gums..All.the.tablet. formulations. showed. acceptable. pharmacotechnical. properties. and. complied. with. in‐house. specifications. for. tested. parameters.. In. the.further.formulation.development.process,.F8.(55%.guar.gum.with.10%.acacia),.the.most.successful.formulation.of.the.study,.exhi bited.satisfactory.drug. release.and.could.extend.the.release. up. to. 12. hours..The. mechanism. of. drug.release. from.all. the.formulations. was. diffusion.coupled.with.