ION ASSOCIATION METHOD FOR THE DETERMINATION OF SUMATRIPTAN SUCCINATE FROM TABLET DOSAGE FORMS USING TROPAEOLIN OOO

摘要

A.simple,.sensitive,.rapid.and.accurate.extractive.spectrophotometric.method. has.been.developed.for.the.determination.of.sumatriptan.succinate.from.bulk.and.tablet.dosage.forms...The.method.is.based.on.the.formation.of.orange.red.colored.chloroform.extractable.ion‐pair.complex.between.the.basic.nitrogen.of. the.drug.and.acidic.dye.Tropaelin.ooo.(TPOOO) .in. the.presence. of.0.1M.HCl.with.an.absorption.maximum.of.482.5.nm..The.calibration.graph.is.linear.over.the.concentration.range.of.2‐10μg/ml.and.its.Molar.absorptivity.and.Sandell's.sensitivity.are.2.0830x104.l/mol/cm.and.0.019851.μg/cm2/0.001.absorbance. units. respectively.. The.proposed.method. is. applied.to. commercial. available.tablets.and. the. results. are.statistically.compared.with.those.obtained.by.the.UV.reference.method.and.validated.through.recovery.studies