TABLETED DOSAGE FORM OF FELODIPINE WITH MODIFIED RELEASE, METHOD AND COMPOSITION FOR MAKING SAID TABLETED DOSAGE FORM AND MEDICAL APPLICATION

摘要

FIELD: medicine.;SUBSTANCE: pharmaceutical composition for making tableted dosage form with modified release for oral administration of calcium channel blocker-felodipine contains felodipine or its pharmaceutically acceptable salt, a carrier for modified release and a hydration gel accelerator. The carrier for modified release is a salt of alginic acid with an alkali metal. The hydration gel accelerator is hydroxypropyl methylcellulose.;EFFECT: provision for relatively fast (during several hours) release of felodipine, with simultaneous prolonged retention of its concentration in blood plasma at a stable high level, and is characterised by low cost of production.;20 cl, 1 dwg, 2 tbl, 3 ex