DEVELOPMENT AND CHARACTERIZATION OF LAMOTRIGINE ORODISPERSIBLE TABLETS: INCLUSION COMPLEX WITH HYDROXYPROPYL β CYCLODEXTRIN

摘要

The. present. study. aimed. at. preparing. Orodispersible. tablets. of. lamotrigine. by. forming. inclusion. complex. with. hydroxypropyl. β‐cyclodextrin.(HPβCD).employing.kneading.method..The.complex.was.compressed.into.tablets.along.with.superdisintegrants.such.as.Kyron.T‐314,.Sodium.starch.glycolate,.Indion.414,.Croscarmellose.sodium.and.crospovidone.i n. different.concentration..Bitter.taste.of. drug.is. successfully.masked.by.HPβCD.complex.and.is.also.useful.to.enhance.the.solubility.which.was.confirmed.by.phase.solubility.analysis..Orodispersible.tablets.were.characterized.by.Fourier. Transform. Infrared. (FTIR). Spectroscopy,. Differential. Scanning. Calorimetry. (DSC). and. Powder. X‐ray. Diffraction. Analysis. (PXRD).. The.prepared. tablets.were.evaluated.for. weight.variation,.thickness,.hardness,. friability,. in. vitro.dispersion.time,.wetting. time,. in. vitro. disintegration.time,. drug. content. and. in. vitro. drug.release.. In. vitro. dispersion. time. decreases. with. increase.in. concentration. of. all. superdisintegrants.. Result.revealed.that.F6.had.shown.short.dispersion.time.with.maximum.drug. release. in. 12. minutes..Formulation. containing. higher. concentration. of.Indion.414.decreases.disintegration.time.(22.71.sec).and.optimize.the.drug.release.(99.09%.in.12.minutes)..