PREPARATION AND IN-VITRO ASSESSMENT OF MUCOADHESIVE BUCCAL PATCHES CONTAINING CARVEDILOL

摘要

Mucoadesive. patches.for. the.delivery.of.carvedilol.were.prepared.using.chitosan,. a.cationic.polymer.. Solvent.casting.technique.was.used.for.the.purpose. of. preparation. of. buccal. patches.. Different. physico‐chemical. properties. like. content. uniformity,. thickness,. surface. pH,. radial. swelling,.residence.time.and. bioadhesive.force.were.determined.. In-vitro.drug.release.was.carried.out.in.USP.dissolution.apparatus..For.in‐vitro.residence.time,. all. patches,. except. C‐2. ( 2%. m/v. chitosan). remained. attached. to. the. mucosal. surface. till. complete. erosion.. Maximum. bioadhesion. was.recorded.for.C‐1.(1%.m/v.chitosan),.followed.by.the.C‐3.(3%.m/v.chitosan),.then.C‐2.(2%.m/v.chitosan)..The.in-vitro.drug.release.within.1h.from.C‐1,.C‐2.and.C‐3.patches.was.10.96%,.15.42%.and.12.32%.respectively,.and.after.8.h.it.was.found.37.77%,.50.23%,.and.42.87%.respectively..Non