IN VITRO ANTIOXIDANT ACTIVITY OF HINDERED PIPERIDONE DERIVATIVES

摘要

The.present. study.was.designed.to.synthesize.isomeric.alcohols.from.corresponding.piperidone. 1.by.sodium.ethoxide.reduction.and.the.alcohols.were.separated.by.column.chromatography..The.synthesized.compounds.were.characterized.by.IR,.1H,.1 3C.NMR.studies..In.addition.to.that.in.vitro.potential.antioxidant.activity.of. the.compounds.was.analyzed.via. DPPH. assay.and.compared.with.standard.antioxidant. such.as.Ascorbic.acid. and.proposed.the.suitable.mechanism.of.antiradical.action..It.has.been.found.that.piperidone.1.demonstrated.excellent.radical.scavenging.activity,.much.better.than.its.isomeric.alcohols.2.and.3..