Effective Synergetic Catalytic System For The Efficient Synthesis Of Multicomponent Biginelli-Type Pyrimidinone Derivatives

摘要

A simple, clean and efficient Biginelli-type reaction was reported towards single-pot synthesis of pyrimidinone derivatives using cyclopentanone, aryl aldehyde and urea/thiourea. In this transformation niobium pentachloride acts as excellent catalyst in presence of silver salt. Under identical experimental conditions, thiourea exhibited similar behavior as compared to urea.