Germ cell tumors represent only 20% to 25% of all benign and malignant ovarian neoplasms. Mixed germ cell tumors are a rare variety of non–dysgerminomatous germ cell tumors. They contain two or more elements; the most frequent combination being a dysgerminoma and an EST (Endodermal Sinus Tumor). We present a case of malignant mixed germ cell tumor comprising of yolk sac tumor, embryonal carcinoma and choriocarcinoma. A 13-year-old girl presented with a huge 25 x 18 cm mass in abdomen with raised values of CA-125, hCG, AFP (alpha-feto protein) and LDH (lactate dehydrogenase). She underwent laparotomy followed by unilateral salpingoopherectomy and infracolic omentectomy. Histopathology report revealed malignant mixed germ cell tumor comprising predominantly of EST with elements of embryonal carcinoma and non-gestational choriocarcinoma. Following surgery, she was started on adjuvant chemotherapy (Bleomycin, Etoposide and Cisplatin regimen). Mixed germ cell tumor (YST/EST, non-gestational choriocarcinoma and embryonal carcinoma) is a very rare tumor. Careful initial surgery with adequate staging biopsies followed by combination chemotherapy can greatly improve the prognosis of these patients.
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机译:生殖细胞肿瘤仅占所有良性和恶性卵巢肿瘤的20%至25%。混合生殖细胞肿瘤是罕见的非非泌尿生殖型生殖细胞肿瘤。它们包含两个或多个元素;最常见的组合是dysgerminoma和EST(内胚窦肿瘤)。我们介绍了一个由卵黄囊肿瘤,胚胎癌和绒癌组成的恶性混合生殖细胞肿瘤的病例。一名13岁女孩腹部巨大25 x 18 cm肿块,CA-125,hCG,AFP(甲胎蛋白)和LDH(乳酸脱氢酶)升高。她接受了剖腹手术,随后进行了单侧输卵管切除术和经结肠直肠网膜切除术。组织病理学报告显示,恶性混合生殖细胞肿瘤主要由EST和胚胎癌及非妊娠绒毛膜癌组成。手术后,她开始接受辅助化疗(博来霉素,依托泊苷和顺铂方案)。混合生殖细胞肿瘤(YST / EST,非妊娠性绒毛膜癌和胚胎癌)是一种非常罕见的肿瘤。仔细的初次手术,适当的分期活检以及联合化疗可以大大改善这些患者的预后。
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