The Emerging Usage and Applications of Nanotechnology in Food Processing Industries: The new age of Nanofood

摘要

Scopoletin, a derivative of coumarin, is a benzopyrone in nature, and present in the various plants. In the present study, scopoletin at a dose of 1mg/kg p.o. once a day and scopoletin at a dose of 1mg/kg p.o. at two times in a day was evaluated for the hypoglycemic and hypolipidemic activity in Wistar albino rats in streptozotocin induced diabetic rats. Glimepiride (0.11mg/kg) was used as reference standard for the activity comparison. Fasting blood glucose level and plasma lipid profiles were measured in diabetic and non diabetic rats at the end of the experiment. Scopoletin showed significant reduction in blood glucose level and lipid level in streptozotocin induced diabetic rats that is comparable to Glimepiride, with more promising decrease in glucose concentration observed in scopoletin two times a day than the scopoletin given once a day. The finding of the present investigation showed that the scopoletin at 1mg/kg dose is very helpful in diabetes and its complication. It showed the significant anti hyperglycemic and anti hyperlipidemic activity in Streptozotocin induced diabetic rats.