In Vitro Cytotoxic Effect of Indole Alkaloids from the Roots of Kopsia singapurensis RIDL. against the Human Promyelocytic Leukemia (HL-60) and the Human Cervical Cancer (HeLa) Cells”

摘要

Yield of fruit bodies in medicinal mushroom is considered as important criteria in the cultivation. Fruit body initiation in mushroom was controlled by several physical and metabolic parameters. Hence the current research was carried out to investigate the fungal bacterial interaction explored for the initiation of fruit body in medicinal mushroom. The antagonistic activity between the fungi and bacteria were studied on dual plate method and found to be compatible. We found that free living nitrogen fixing Azotobacter initiate the basidiome in Hypsizygus ulmarius and not in Pleurotus aureovillosus, and Volvariella volvaceae. The current research suggests that, in cultivation of medicinal mushroom Hypsizygus ulmarius, Azotobacter can be co-inoculated in the substrate as basidiome inducer. Further studies on molecular signaling between the fungi and bacteria have to be explored using recent molecular tools like transcriptome.