Microparticulate Formulations and Physicochemical Evaluation of Poorly Water Soluble Drugs by Using Spray Drying Technique”

摘要

Apolipoproteins play a significant role in lipid transport and metabolism through binding to lipid to form lipoproteins. Moreover, Apolipoproteins have several roles rather than lipid transportation such as co-factor for enzymes to transport the lipid molecules to cells and act as a ligand to lipoprotein cell receptors. Apolipoproteins are categorized into two main types and several subunits: exchangeable such as Apo B which anchored in lipoprotein and non-exchangeable like Apo A, E, D, and C which can transfer from one lipoprotein to another. Apo A1 and Apo B-100 are the major component of high-density lipoprotein (HDL) and low-density lipoprotein (LDL). These apolipoproteins are involved in many disorders and mainly dyslipidaemia, particularly atherosclerosis. Many studies are reported that Apo B is an atherogenic protein which can be oxidized and stimulate the immune cells to build up the plaque. However, Apo A, E and D may play as atheroprotective protein in different ways as shown by several experiment. In conclusion, Apolipoproteins have significant role in atherogenesis and its effect vary with different classes and subunits.