FORMULATION AND IN VITRO EVALUATION OF SALBUTAMOL SULPHATE SUSTAINED RELEASE TABLET BY USING FLOATING DRUG DELIVERY TECHNOLOGY

摘要

The present study involves in the preparation and evaluation of floating tablets of Salbutamol sulphate by direct compression method by using the hydrophilic polymer such as hydroxy propyl methyl cellulose (HPMC), Sodium carboxy methyl cellulose, Dextrin and Carbopol. Sodium bicarbonate, Tartaric acid and citric acid were incorporated as gas generating agent. The study aims to achieve different formulations using different polymers in order to find out the most suitable and successful type of polymer. The prepared tablets were evaluated in terms of thickness, average weight, hardness, friability, drug content uniformity, swelling index, in- vitro buoyancy study and in-vitro dissolution study. The formulated tablet Hardness was found to being the range of 2.6 to 3.8 kg/cm2, the % friability was in the range of 0.30 to 0.50. The Swelling Index and floating time of different formulations range from 1.78 to 16.15 and 8.15 to 12 hrs respectively. In-vitro release studies were carried out using USP XXII dissolution test apparatus. The tablet containing Salbutamol sulphate was released from batch F1-F10 found to be 78.55 to 98.55 %. The release of drug from tablets sufficiently sustained for 8 hours by in vitro release study. From the ten formulations we found that the formulation containing Carbopol (F₇) were showed the better sustain release when compared to the other formulations.