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Preparation and characterization of superporous hydrogel based on different polymers

机译:基于不同聚合物的超孔水凝胶的制备与表征

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Introduction:Superporous hydrogel (SPH) swells very rapidly in a shorter period of time to an equilibrium size and contains highly porous structure.Aim:The synthesis of SPH of poly (acrylamide-co-acrylic acid) and its composites viz. Ac-Di-Sol and polyvinylpyrollidone (PVP) was carried out by solution polymerization.Materials and Methods:The SPH and SPH composites (SPHCs) were characterized by measurement of apparent density, porosity, swelling, mechanical strength, and scanning electron microscopy (SEM) studies.Results:FTIR studies confirmed the existence of acrylamide and acrylic acid in SPH. In distilled water SPH showed tremendous increase in equilibrium swelling capacity with conventional SPH as compared to its SPHCs of Ac-Di-Sol and PVP due to the increased in physical cross-linking network, respectively. The presence of Ac-Di-Sol and PVP in SPHCs increased the mechanical strength as compared to conventional SPH which is suitable for gastric retention. SEM pictures clearly indicated the formation of interconnected pores and capillary channels.Conclusion:The amount and type of polymers used affect almost all the characterization parameters of SPHs, and hence, depending upon the applications perspective such polymers could be used in drug delivery systems, successfully.
机译:简介:超多孔水凝胶(SPH)在较短时间内迅速膨胀至平衡尺寸,并具有高度多孔的结构。目的:聚丙烯酰胺-丙烯酸共聚物及其复合材料的SPH合成。通过溶液聚合反应制得Ac-Di-Sol和聚乙烯吡咯烷酮(PVP)。材料与方法:通过测量表观密度,孔隙率,溶胀,机械强度和扫描电子显微镜(SEM)表征SPH和SPH复合材料(SPHC)。结果:FTIR研究证实了SPH中存在丙烯酰胺和丙烯酸。在蒸馏水中,由于物理交联网络的增加,与传统SPH的Ac-Di-Sol和PVP的SPHC相比,SPH的平衡溶胀能力大大提高。与适合胃retention留的常规SPH相比,SPHC中Ac-Di-Sol和PVP的存在提高了机械强度。 SEM照片清楚地表明了相互连接的孔和毛细血管通道的形成。结论:所用聚合物的数量和类型几乎影响了SPH的所有表征参数,因此,根据应用的观点,此类聚合物可成功用于药物输送系统。

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