Preparation and Characterization of Swellable Polymer based Gastro-Retentive Zidovudine Superporous Hydrogel Composite

摘要

The main objective of this research work was to prepare and characterize zidovudine superporous hydrogel composite (sphc). Zidovudine is an anti retroviral agent well absorbed from stomach belongs to the class of narrow therapeutic window so there is a need to prepare a gastro retentive dosage form. Superporous hydrogel composite is a second generation sph. For this preparation acrylic acid, acrylamide monomers were used which shows high water absorbing affinity, N,N methylene bisacylamide was used as a crosslinking agent, N,N,N~(1),N~(1)Tetrametylethyelenediamine, ammoniumpersulphate as a polymerization initiator pair. Sodiumbicarbonate was used as a gas blowing agent which aids in formation of pores in the structure of sphcomposite. In sphC Ac-Di-Sol was used as a composite material which enhances the mechanical strength of sphC. To characterize the prepared zidovudine sph composite evaluation tests which include swelling ratio, swellingtime, scanning electron microscopy (SEM) analysis were performed, and dissolution studies were carried out to assess release characteristics.