ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF HEARTWOOD OF BIJASAR (PTEROCARPUS MARSUPIUM ROXB.) IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED TYPE 2 DIABETIC RATS

摘要

The antidiabetic potential of ethanolic extract of bijasar (Pterocarpus marsupium Roxb.) heartwood was evaluated in the streptozotocin-nicotinamide induced type 2 diabetic model. Graded doses of the ethanolic heartwood extract were administered to normal and experimental diabetic rats for 12 days. Significant (p < 0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animals. In addition, changes in body weight, serum lipid profiles, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels assessed in the extract treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the bijasar heartwood by Indian herbal practitioners for treatment of diabetics in different part of the Indian subcontinent.