Role of Solvents and Stabilizer in the Preparation of Solid Lipid Nanoparticles of Stearic Acid by Ultrasound Assisted Nanoprecipitation Method

摘要

This article describes the preparation and characterization of solid lipid nanoparticles (SLN) of stearic acid with two different stabilizer systems and mixture of solvents in order to study the influence of solvents and surfactants on the size of the nanoparticles, degree of dispersion, stability and crystallinity of the SLN. A 1:1 mixture of TWEEN-80 and SDS and another stabilizer system containing 1:1 mixture of CTAB and PVP were used as stabilizes. Acetone, mixture of acetone and THF and ethanol were used as solvents. The SLN were characterized by time-resolved particle size analysis, zeta potential measurements, differential scanning calorimetry (DSC) X-ray diffraction (XRD), Transmission electron microscopy(TEM) and FTIR. Results indicate that the SLN produced with the stabilizer system of TWEEN-80 and SDS have lower crystallinity, larger particle sizes, lower melting point as compared with SLN prepared with PVP and CTAB. However the polydispersity indexes for the suspensions are lower than the SLN prepared with PVP and CTAB indicating higher stability. FTIR spectra reveals that there is no structural change occur in all the SLN.