Multiple intraosseous lipoma (MIOL) is extremely rare bone tumour. Its real incidence is estimated as much more because of most of these tumours is asymptomatic and undiagnosed. We reported 3 MIOL patients involving both upper and lower extremity. Two female patient with 30 and 26 age and one male with 52 years old represented by intraosseous lipomatous lesions involving bilateral wrist and hand bones, distal radius, proximal and distal femur, patella, proximal and distal tibia metaphyses, distal fibula, ankle and foot bones. Painful lesions were curetted and grafted by allograft. A distal radius fracture is treated by closed reduction and percutaneus pining. All the lesions healed that is managed by surgery. The asymptomatic lesions were not treated anyway. MIOL needs surgery in the case of pain, pathologic fracture, pathologic diagnosis confirmation and impending fracture. The malign transformation potential is present even rare. It must be followed in long period and carefully. CT is a good diagnostic imaging allowing negative density measurement in lesions between -60 and -110 HU.
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