The Effect of Trigonella Foenum Graecum (Fenugreek) on the Blood Glucose, Lipid Profile and α-Amylase for Diabetic Albino Rats Compared with Solenstomma Hargel

摘要

Objective: This study aimed to compare the antidiabetic effects of some Sudanese plants used traditionally by diabetic patients in Khartoum state, Sudan. The problem of this study lied under that Sudanese diabetic patients using some Sudanese medicinal plants without knowing their pharmaceutical effect and their dose. Materials & Methods: The essays of the present study were conducted on albino rats which obtained from the faculty of pharmacy, University of Khartoum, Sudan. Forty two albino rats of either sex weighing (135-250g) and aged two months were used. Six animals were serve as control (group 1), thirty six animals treated groups (2, 3, 4, 5, 6 and 7) (N=6). Dexamethasone (10mg/kg .b.w) for 10 days is used to induce hyperglycemia and Hyperlipidemia after eighteen hours fasting. Groups (2, 3 and 4) were administered with three different doses of Trigonella foenum graecum ( Fenugreek) aqueous extract (200, 400 and 800mg/kg-b.w) respectively, groups (5, 6 and 7) were administered with three different doses of Solenstomma Hargel aqueous extract (200, 400 and 800mg/kg-b.w) respectively. Blood specimens were collected from each group after2 and 4 hours, serum levels of blood glucose, lipid profile and α-amylase concentrations were estimated. The plants used in this experiment clearly demonstrate the non-toxic nature and safety profile. The combined history human use of these plants and the data from the current study support the safe use of these plants. Result: The results obtained from this study showed that Trigonella foenum graecum ( Fenugreek) and Solenstomma Hargel aqueous extract had significant hypoglycemic effect more over they have reducing effect on lipid profile. Solenstomma Hargel aqueous extract had un expected increase in α-amylase level at high concentration compared to Trigonella foenum graecum ( Fenugreek) which have decreasing effect. Conclusion: It can be concluded from this study that Trigonella foenum graecum ( Fenugreek) had more hypoglycemic effect at small dose (200mglkg.-b.w) when compared with Solenstomma Hargel aqueous extract. The two extracts had significant hypoglycemic effect more over with no side effect.