High prevalence of bronchiectasis in emphysema-predominant COPD patients

摘要

Background: COPD has been identified as an etiology or related disease of bronchiectasis, and bronchiectasis has been classified as a comorbidity of COPD. In this study, we investigated the prevalence of bronchiectasis in different phenotypes of COPD subjects and the correlation between bronchiectasis and different phenotypes, especially emphysema. Methods: COPD patients were recruited from April 2012 to December 2015. The presence of bronchiectasis and related information were statistically analyzed. COPD subjects were separated into subgroups in two ways: COPD with and without bronchiectasis groups and emphysema-predominant (emphysema index, EI≥9.9%) and non-emphysema-predominant (EI1% predicted, P 1% predicted (OR, 1.636; 95% CI, 1.219–2.197; P =0.001) and EI (OR, 1.993; 95% CI, 1.199–3.313; P =0.008) were significantly related with the presence of bronchiectasis in COPD patients. Conclusion: The proportion of bronchiectasis is higher in emphysema-predominant COPD subjects. Emphysema measured by EI and FEV₁% predicted are independent predictors for bronchiectasis in COPD subjects, while the underlying mechanism deserves further investigation.