Electrochemical Investigation of Isoniazid on Poly (p-Aminobenzene Sulfonic Acid) Film Modified Glassy Carbon Electrode

摘要

Isoniazid is a tuberculostatic agent effective active compound. A glassy carbon electrode (GCE) wasmodified with an electropolymerized film of p-aminobenzene sulfonic acid (p-ABSA) in phosphatebuffer solution (PBS). The electrochemical properties of isoniazid on modified electrode were studiedby cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The polymer film- modified electrode was used to electrochemically detect isoniazid. The polymer film had excellentelectrocatalytic activity for the oxidation of isoniazid. A linear calibration curve for DPV analysis was-5 -4 -1 constructed in the isoniazid concentration range 2x10 - 1x10 mol L . Limit of detection (LOD) and-6 -5 -1limit of quantification (LOQ) were obtained as 3.05x10 and 1.01x10 mol L respectively. Isoniazidwas determined in tablet dosage form. The proposed method exhibits good recovery andreproducibility. The mechanisms of electropolymerization were also suggested.