Enzyme-Free Glucose Sensor Based on Micro-nano Dualporous Gold-Modified Screen-Printed Carbon Electrode

摘要

In this work, an enzyme-free glucose sensor at neutral pH (7.4) has been developed based on a micronano dualporous (MNDP) gold-modified screen-printed carbon electrode (SPCE). The combination ofMNDP gold and SPCE makes the device a compact, low-cost and reliable enzyme-free glucose sensor.MNDP gold was directly synthesized via an electrochemical deposition method on a carbon surfaceusing a hydrogen bubble as a dynamic template. The obtained MNDP gold has a highly porousstructure and is mechanically stable. The MNDP gold-modified SPCE was applied to glucose sensing.This enzyme-free sensor showed a wide linear range, with the logarithm of glucose concentrationbetween 1.5 and 16 mM, a high sensitivity of 48.4 μA.mM-1.cm-2, and a limit of detection of 25 μM. Italso exhibited exquisite selectivity with the common interference compounds in real samples.Moreover, this sensor successfully detects glucose levels in human blood serum with satisfactoryresults and functional recovery.