Low-Potential Amperometric Determination of Reduced Glutathione at Physiological pH with an Electrodeposited Cu Nanoparticles Modified Pt Electrode

摘要

The electrodeposition of Cu nanoparticles was investigated at Pt electrode in 10 mM Cu(NO3)2 in thepresence and absence of NH4Cl. Pure Cu nanoparticles was synthesized in a solution containingNH4Cl, and Cu/Cu2O composite film was obtained without NH4Cl. In addition, rare Cu decanedronswas electrochemically synthesized in 10 mM Cu(NO3)2+0.1 M NaNO3. The electrodeposited Cunanoparticles exhibits excellent electrocatalytic activity toward oxidation of reduced glutathione(GSH) at a super low potential and the electrocatalytic mechanism was discussed, which was first usedfor the electrochemical determination of GSH at physiological pH. Furthermore, the commoninterfering species, including ascorbic acid (AA), dopamine (DA), uric acid (UA), and glucose, wereexamined for the electrochemical detection of GSH, and the results showed that the oxidation from theinterfering compounds was effectively avoided because of the super low detection potential.