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Mathematical Modeling of Multienzyme Biosensor System

机译:多酶生物传感器系统的数学建模

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A mathematical model of hybrid inhibitor biosensor system is discussed. This model consists of five nonlinear partial differential equations for bisubstrate sensitive amperometric system. Simple and closed form of analytical expressions for concentration of glucose-6-phosphate (substrate), potassium dihydrogen phosphate (inhibitor), oxygen (co-substrate), glucose (product 1), and hydrogen peroxide (product 3) is obtained in terms of rate constant using modified Adomian decomposition method (MADM). In this study, behavior of biokinetic parameters is analyzed using this theoretical result. The obtained analytical results (concentrations) are compared with the numerical results and are found to be in satisfactory agreement.
机译:讨论了混合抑制剂生物传感器系统的数学模型。该模型由用于双基体敏感安培系统的五个非线性偏微分方程组成。分别按以下公式获得了葡萄糖-6-磷酸葡萄糖(底物),磷酸二氢钾(抑制剂),氧气(共底物),葡萄糖(产物1)和过氧化氢(产物3)的浓度的分析表达式的简单和封闭形式。使用改进的Adomian分解方法(MADM)确定速率常数。在这项研究中,使用该理论结果分析了生物动力学参数的行为。将获得的分析结果(浓度)与数值结果进行比较,发现结果令人满意。

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