Correlation between the insertion/deletion polymorphism of the angiotensin conversion enzyme gene and hypertension among the Gabonese population

摘要

I/D polymorphism of the Angiotensin Converting Enzyme gene (ACE), seems to be an excellent marker of risk of the hypertension. The study was carried out in order to determine the relationship between arterial hypertension and the polymorphism of the ACE gene among the Gabonese population. In total 132 patients were enrolled of which 95 hypertensive patients (cases) and 37 normotensive subjects (controls). The 287bp sequence in intron 16 of the ACE gene were identified by a conventional PCR. Statistical analysis and calculation of the odds ratio were applied to compare distributions of alleles I and D between hypertensive and non-hypertensive subjects. The frequencies of the genotypes DD, ID and II were 53%, 39.4% and 7.6% respectively in the study population. The DD genotype was approximately 3 times greater in cases 55 (78.60%) than in controls 15 (21.40%). The D allele was 3 times higher among cases (75%) than controls (25%). I/D polymorphism of the ACE gene seems to be associated with a risk for hypertension but the correlation was not significant (OR=1.55, p=0.15). These results showed that the genotypes DD, ID, II were not involved in the occurrence of hypertension in Gabonese population leading to cardiovascular diseases.