An Evaluation of dark sesame seeds versus white sesame on blood glucose, oxidative stress markers, and kidney function in streptozotocin-induced diabetic rats

摘要

Sesame seeds have been the focus of recent studies due to their potential nutritional value and chemical composition. Forty-eight albino Sprague Dawley rats were divided into 4 groups (12 rats each in group):Group 1—the normal control group, Group 2—the diabetic control group, Group 3—the diabetic group that received the standard diet+15% dark sesame seeds, and Group 4—the diabetic group that received the standard diet+15% white sesame seeds for 6 weeks. Diabetes was induced by a single dose of streptozotocin (60 mg/kg body weight).The levels of blood glucose, (MDA) malondialdehyde, serum creatinine, urea, and Uric acid were statistically lower in G3 and G4 than in G2 (P0.05). Total antioxidants (TAC) were statistically higher in G3 and G4 than in G2 (P0.05).No significant difference was found between G3 and G4 in blood glucose. However, G3 showed a significant improvement in MDA and TAC, serum creatinine, urea, and uric acidcompared to G4 (P0.05). Consuming both dark and white sesame seeds can improve blood glucose, oxidative stress markers and kidney function in streptozotocin-induced diabetic rats. Therefore, sesame seeds area potential protective natural agent against diabetes complications.