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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Comparative study of tramadol and piroxicam as analgesic for postoperative pain in patients operated for inguinal hernia and hydrocele
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Comparative study of tramadol and piroxicam as analgesic for postoperative pain in patients operated for inguinal hernia and hydrocele

机译:曲马多和吡罗昔康镇痛治疗腹股沟疝和鞘膜积液患者术后疼痛的比较研究

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摘要

Background: Pain is usually protective, it warns of tissue damage and prompts treatment but postoperatively, it can delay recovery. Postoperative pain is both distressing and detrimental for the patient. Postoperative pain may be a significant reason for delayed discharge from hospital, increased morbidity and reduced patient satisfaction. Methods: This was a hospital based prospective, randomized, comparative, observational study conducted over a period of one year. Patients operated for hydrocele and inguinal hernia were included in the study after applying the inclusion and exclusion criteria. For the purpose of study, equal numbers of subjects were randomly allocated one of the two analgesic protocols. Pain assessment was done by using visual analog scale (VAS) for the first 72 hours of the postoperative period. Results: When the drugs were compared individually, piroxicam was superior to tramadol in first 24, 48 and 72 hours of postoperative period in case of pain after surgery for hernia. Piroxicam was found to be superior to tramadol in first postoperative 24 hours after surgery for hydrocele with no significant difference first 48 & 72 hours of postoperative period. Piroxicam has the advantage of requiring lesser frequency of administration than tramadol due to prolonged duration of action. Conclusions: Piroxicam provides better and effective analgesia in acute post-operative pain along with the advantage of requiring lesser frequency of administration than tramadol.
机译:背景:疼痛通常是保护性的,可警告组织损伤并提示治疗,但术后会延迟恢复。术后疼痛对于患者而言既是痛苦的也是有害的。术后疼痛可能是延迟出院,发病率增加和患者满意度降低的重要原因。方法:这是一项基于医院的前瞻性,随机,比较,观察性研究,为期一年。应用纳入和排除标准后,将因鞘膜积液和腹股沟疝手术的患者纳入研究。为了研究的目的,将相等数量的受试者随机分配为两种镇痛方案之一。在术后的前72小时使用视觉模拟量表(VAS)进行疼痛评估。结果:单独比较药物时,在疝气手术后出现疼痛的情况下,吡罗昔康在术后24、48和72小时内优于曲马多。在皮下积液的术后24小时内,发现吡罗昔康优于曲马多,术后48小时和72小时无明显差异。由于作用时间延长,吡罗昔康具有比曲马多需要更少的给药频率的优点。结论:吡罗昔康在急性术后疼痛中提供更好,更有效的镇痛作用,并且具有比曲马多更少的给药频率的优势。

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