Cervical cancer is the fourth most common cancer inwomen, and the seventh overall, with an estimated 528,000 new casesand 266,000 deaths from cervical cancer worldwide in 2012. Thecausative agent of cervical cancer is Human Papillomavirus (HPV)and HPV 16 and 18 are the main causative types .There are reportsdedicated towards the characterization of the genetic contribution tothe disease variance, with many modifiers gene for cervical cancer.In this study we have undertaken a normalization approach toidentify the differential regulation of genes in cervical cancer byanalyzing cervical cancer microarray data sets from GEO database.EPHA3 gene belongs to the ephrin receptor subfamily of the proteintyrosine kinase family and its expression has been reported in manytypes of cancers. We investigated the role of EPHA3 gene; found tobe 3-fold down regulated, in cervical cancer. Our results suggest thatthe lower levels of EPHA3 may lead to RAS activation, causinguncontrolled differentiation and proliferation, thus playing a key rolein metastasis.
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