HEPATOPROTECTIVE EFFECT OF ETHYL ACETATE EXTRACT OF Terminalia arjuna ROOT ON HCB INDUCED LIVER CARCINOGENESIS IN FEMALE ALBINO WISTAR RATS

摘要

Cancer has been a dreadful and complex disease of present century. The use of various anticancer compounds from plants for human healthcare still remain the most widely used medication system in developing and least developed nation. Compounds possessing anticancer properties have been identified in fruits, vegetables, spices, and medicinal plants. Terminaliaarjuna is a widely used medical plant throughout India. The anticancer effect of T. arjuna were studied on albinowistar rats treated with T. arjuna crude and its extract from root. Therefore the root of T. arjuna were found to have anticancer activity. According to experiment, designed five groups of rats was evaluated the beneficial properties of T. arjuna consumption on liver marker enzyme regulation and lipid peroxidation in albino rats in HCB induced stage. For the study, the female albino rats were divided into five groups, normal, corn oil control, chemical treated, chemical along with the crude and its extract of plants treated groups for initiation phases. The treatment of HCB caused carcinogenesis for 30 days and the other group had plant crude and its extract treatment up to 30 days. Effects of T. arjuna consumption on LPO and liver marker enzymes were also evaluated. The plant treatment had remarkable effects on LPO and liver marker enzymes level in the female albino rats. An improvement in lipid peroxidation and liver marker enzymes were observed with lower lipid peroxidation and liver marker enzymes after 30 days of T. arjuna.