Efficacy of Ceftobiprole in Treating of Osteomyelitis Due to Methicillin Resistant Staphylococcus aureusin Rabbits

摘要

The present study was carried out to investigate antibacterial activity of ceftobiprole and vancomycin in-vitro and in-vivo after inducing osteomyelitis in rabbit by administration of Methicillin Resistant Staphylococcus Aureus (MRSA). Part I, evaluation is done in-vitro by using hot plate method for appearance zone of inhibition and Minimum Inhibitory Concentration (MIC) against (MRSA). Antibacterial susceptibility test showed that the ceftobiprole was more effective than vancomycin. Part II, inducing osteomyelitis (40 mg/kg B.W) compared with treated with vancomycin at a dose of (30 mg/kg B.W) subcutaneously for 28 days. Ceftobiprole succeeded to treat osteomyelitis by absence methicillin resistant staphylococcus aureus in the infected rabbits and prevented infection compared with vancomycin and radiographic pictures explained normal bone anatomy and all features of osteomyelitis disappeared These results indicate that ceftobiprole provided effective parenteral treatment of osteomyelit is in this rabbit model.