ALUMINUM AND FLUORIDE IMPACTS CORTEX, HIPPOCAMPUS AND DENTATE GYRUS STRUCTURE IN RATS: PROTECTIVE ROLE OF RESVERATROL

摘要

Metals such as aluminum and Fluoride have been implicated in the etiology of several neurodegenerative disorders. Resveratrol, a natural polyphenol, exerting a wide range of biological and pharmacological activities including its antioxidative properties against neurodegenerative disorders through its ability to lessen oxidative stress. Rats were divided into 4 groups. Group –I was served as control. Group –II was intoxicated with Alcl₃ (100 mg/kg b.w) along with Sodium fluoride (10 mg/kg b.w). Group –III was administered with Alcl₃ (100 mg/kg b.w) + Sodium fluoride (10 mg/kg b.w) + resveretrol (30 mg/kg b.w). Group–IV was administered with resveretrol (30 mg/kg b.w) alone for 8 weeks. The obtained results showed significant oxidative stress induced neuronal damage in cerebral cortex and hippocampus in intoxicated rats where as significant reduction in neuronal damage in the rats administered with resveratrol against aluminium along with fluoride when observed with certain stains. Hence, the results of the present study reveal that the resveratrol has potential neuroprotective properties to diminish the oxidative stress on Cortical and Hippocampal neuronal loss and cognitive impairment by aluminum and fluoride intoxication.