Evaluation ofOxidative Stress Indices afterExposure to Malathion&Protective Effects of VitaminC inOvarian Tissue ofAdult FemaleRats

摘要

Background:Malathion is an organophosphate pesticide which is known to induce oxidative stress in the targettissues such as the reproductive system.The aim of present study was to evaluate the effects of malathion onmalondialdehyde(MDA) and glutathione(GSH) levels in female rat reproductive tissue (ovary) and to assess theprotective role of vitamin C.Materials and Methods:In this experimental study, 30 adult female Wistarrats (weight range: 200-250 g) weredivided into five groups,consisting of six rats: control group (no interventions), sham group (normal saline),experimental group 1 (malathion+normal saline 50 mg/kg ), experimental group 2 (200 mg/kg of vitamin C), andexperimental group 3 (similar dosesof vitamin C and malathion). The animals were scarified after two weeks andMDA as a marker of lipid peroxidation and GSH content were measured in ovarian tissue.Results: Malathion reduced GSH content and increased MDA level in ovary compared with the control group(P<0.001). Vitamin C plus malathion increased GSH content but decreased malathion induced MDA elevation inrat ovarian tissue.Conclusion: Oxidative stress contributes to DZN-induced ovarian toxicity.Our results concluded that vitamin Emay have a protective role in this toxicity.