Correlation of carotid intima-media thickness and plaque score with SYNTAX II score in patients with coronary artery disease: An observational study

摘要

Background: Early non-invasive detection of coronary arterydisease (CAD) in asymptomatic subjects is crucial. Carotid ultrasonographyis effective in assessing atherosclerotic lesions. Carotidintima media thickness (CIMT) and plaque score (PS) have beenshown to correlate well with presence of CAD. On the other hand,SYNTAX and SYNTAX II score were introduced to estimate thecomplexity of the lesions. Aim of this study was to find out thecorrelation between CIMT, PS and complexity ofCADas determinedby SS II.Methods: A total of 165 patients were included. All demographic,clinical data, biochemical tests, 2D Echo and coronaryangiography of the study subjects were done. Mean CIMT and PSwere calculated for all the subjects. The correlation between variousparameters was done using Pearson correlation coefficient.Results: Weak correlation was observed with CIMT and moderatecorrelation with PS with SS I, SS II percutaneous coronaryintervention (PCI), SS II coronary artery bypass grafting (CABG). Thesensitivity of CIMT (>0.55) in predicting high SS II PCI was 97.7% andPS (>2.5) was 60.47% and the specificities were 6.33% and 70.89%,respectively. CIMT (>0.55) has got better sensitivity while PS (>2.5)has got better specificity. The sensitivity of CIMT (>0.55) in predictinghigh SS II CABG is 97.59% and PS (>2.5) is 61.45% and thespecificities are 6.10% and 70.73%, respectively. CIMT (>0.55) hasgot better sensitivity while PS (>2.5) has got better specificity. ForCIMT cut off >0.75, the sensitivity for predicting high SS II PCI was58.1% and SSII CABG was 61.4% and the specificities were 59.5% and62.2% respectively. The overall diagnostic accuracy of CIMT (>0.75)SSII PCI and SSII CABG was 58.78% and 61.81%, respectively.Conclusion: SS I, SS II PCI, SS II CABG showed weak correlationwith CIMT and moderate correlation with PS. CIMT (>0.55) hasgot better sensitivity while PS (>2.5) has got better specificity inpredicting high SS II PCI and CABG. For high SS II PCI and CABG duringunivariate analysis, mean CIMT, PS and low-density lipoprotein(LDL) were statistically significant. In multivariate analysis, only PShad shown statistically significant association.