Discovery of AMPK-activated CRH neurons that induce dietary preference for carbohydrate over fat

摘要

Cortical synaptic mechanisms for chronic pain and anxiety The anterior cingulate cortex (ACC) and insular cortex (IC) are two key cortical regions for the process of pain and its related emo- tions. In this talk, I will discuss increasing evidence from rodent studies that ACC/IC activation contributes to chronic pain states and describe several forms of synaptic plasticity that may under- lie this effect. In particular, one form of long-term potentiation (LTP), which is triggered by the activation of NMDA receptors and expressed by an increase in AMPA-receptor function, sustains the affective component of the pain state. Another form of LTP, which is triggered by the activation of kainate receptors and expressed by an increase in glutamate release, may contribute to pain-related anxiety. Finally, I will discuss the potential use of a selective AC1 inhibitor NBOO1 for future treatment of chronic pain and anxiety.