EFFECT OF ETHANOLIC EXTRACT OF BREADFRUIT (ARTOCARPUS ALTILIS [PARKINSON] FOSBERG) LEAVES ON AMELIORATING RENAL FUNCTION OF RAT

摘要

Aims: Kidneys are one of the vital organs which belong to the urinary system. Renal failure occurs when the kidneys are unable to perform excretory functions which are important in maintaining homeostasis. Breadfruit leaves are commonly used empirically for the treatment of renal failure. Objectives: This study aims to determine the influence of breadfruit leaves ethanol extract (BLEE) to improve renal function in the renal failure rat model. Methods: Renal failure model was conducted by administering gentamicin 100 mg/kg body weight (bw) intraperitoneally for 7 days consecutively and piroxicam 3.6 mg/kg bw for 5 weeks which was starting administered with gentamicin. BLEE were given for 4 weeks with dose of 50, 100, and 200 mg/kg bw, after gentamicin induction. Renal functions were evaluated by measuring urea and creatinine serum levels every week and renal histology at the end of the experiment. Results: After induction, urea and creatinine serum levels increased up to 5 times (p<0.05). Both parameters in all groups went up until the 2 week and dropped on the 3 week. There was a significant difference in urea and creatinine serum levels in rats treated by BLEE 200 mg/kg. Histological results depicted an improvement of the kidney structure. That treated by BLEE 200 mg/kg showed similarities appearance with the normal. rd Conclusion: BLEE improved the kidney function in the renal failure model which was showed by reduction on the levels of serum urea and creatinine and restore kidneys structure. BLEE 200 mg/kg bw showed better activity on ameliorating renal function.