ANTI-HYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF SYZYGIUM ALTERNIFOLIUM BARK AGAINST HIGH-FAT DIET AND DEXAMETHASONE-INDUCED HYPERLIPIDEMIA IN RATS

摘要

Objective: The present study is an attempt to investigate its anti-hyperlipidemic activity of methanolic extract of Syzygium alternifolium (MESA) using high-fat diet (HFDs) and dexamethasone-induced hyperlipidemia. Methods: MESA bark was evaluated for anti-hyperlipidemic activity in HFD and dexamethasone-induced hyperlipidemic rats. A comparison was also made between the action of S. alternifolium bark extract and a known anti-hyperlipidemic drug atorvastatin (10 mg/kg body weight). The results of the study were expressed as mean ± standard error, and data were analyzed using one-way analysis of variance test followed by Dunnett’s t-test for multiple comparisons. Values of p<0.05 were considered as significant. Results: Oral administration of 100, 200 mg/kg body weight of the MESA bark exhibited a significant reduction (p<0.01) in serum lipid parameters such as total cholesterol, triglycerides, low-density lipoprotein (LDL), very LDL, and increase in high-density lipoprotein in hyperlipidemic rats of both models as compared to hyperlipidemic control statistically. These extracts were found to possess better anti-hyperlipidemic potential. Conclusion: Our results demonstrated that MESA bark possessed significant anti-hyperlipidemic activity and hence it could be a potential herbal medicine as an adjuvant with existing therapy for the treatment of hyperlipidemia.