PRELUDE STUDIES OF ANTI-DIARRHOEAL ACTIVITY OF ETHYL ACETATE EXTRACT OF AERIAL PART OF INDIGOFERA PURPUREA ON ISOLATED RABBIT ILEUM

摘要

In.Present.study.we.aimed.to.investigate.the.anti‐diarrhoeal.activity.of.ethyl.acetate.extract.of. Indigofera. purpurea.aerial.part,.by.using.castor.oil‐induced.diarrhoeal.model.in.mice..The.effects.of.these.extract.on. perfused. isolated.rabbit.ileum.were. also. evaluated.. The. ethyl.acetate. extract.produced.a.dose.dependent.relaxation.of.the.rabbit.ileum..The.ethyl.acetate.extract.of.aerial.parts.produced.a.dose.dependent.protection.against.the.castor.oil‐induced. diarrhoea.with. the.highest.protection. (85%).at.a.dose.level.of.600mg/kg.comparable.to.that.of.loperamide.(6mg/kg).the.standard.agent.. The.preliminary.phytochemical.analysis. revealed. that.the. extract.contained. tannins,.steroids,.alkaloids,.saponnis. and. flavonoids..The.acute.toxicity.test.revealed.no.mortality.upto.the.dose.of.4500mg/kg..The.results.revealed.that.the.ethyl.acetate.extract.of.Indigofera.purpurea.aerial.part.possess.pharmacological.activity.against.diarrhoea