DEVELOPMENT OF ZOLMITRIPTAN GEL FOR NASAL ADMINISTRATION

摘要

Development of thermoreversible zolmitriptan nasal gel were aimed to improve absorption and patient compliance. In the present research work, mixture of pluronic F-127 (Poloxamer 407) and pluronic F -68 (Poloxamer 188) were used to confer temperature – sensitive gelation property. To modulate the gel strength and bioadhesive force for zolmitriptan nasal gel, bioadhesive polymers such as sodium alginate, sodium carboxymethyl cellulose and polyvinyl pyrrolidone (PVP K–25) were investigated. Incorporation of 2.5 % w/w zolmitriptan in the nasal gel showed no effect on the gelation temperature of the pluronic mixtures, while addition of the bioadhesive polymers had showed increase in gelatio0n temperature. On the other hand these polymers reinforced the gel strength and the bioadhesive force of the prepared nasal gel formulation. The effect was most pronounced with sodium alginate. Increasing the concentration of bioadhesive polymers retarded the release of sumatriptan from the pluronic gel. PVP had less effect on the drug release. Histopathological examination of sheep nasal mucosa with control and optimized formulation did not show any histological damage to the nasal tissue